Andarine (S4) Full Beginner’s Guide 📗 | Jan 2024

Andarine S4 Guide Bodybuilding SARMs Facts

This is the ultimate guide to using the Andarine S4 SARM to build muscle mass, lose body fat, encourage muscle strength, and enhance athletic performance, based on scientific research.

I've been researching SARMs for over 10 years, and selective androgen receptor modulators like Andarine S4 are extremely powerful anabolic compounds, growing in popularity.

Here's what we'll cover today:

  • What is Andarine S4?
  • How Does It Work?
  • Best Andarine Dosage
  • S4 Cycle Examples
  • Does Andarine Need PCT?
  • Andarine S4 Results
  • …and much, much more!

So, if you're interested in using Andarine S4 for bodybuilding, but want to know how to do it safely, and while avoiding the side effects, then keep on reading this guide.

What is Andarine S4?

READ MORE: 7 Best SARMs for Bulking and Cutting in 2024

Andarine is known as a SARM, short for selective androgen receptor modulator. These are relatively new compounds that have the power of anabolic steroids, with minimal side effects.

SARMs like Ostarine and Andarine were initially developed as an investigational drug, to help with treating osteoporosis, but bodybuilders quickly realized how strong these drugs were.

Before you knew it, bodybuilders were using SARMs like Andarine S4 for muscle growth and fat loss left and right. While it was initially developed to fight muscle wasting diseases, scientific data suggests it excels at fat burning and lean muscle gains.

Mechanism of Action

how do sarms work mechanism of action

So, how is Andarine able to create such insane muscle growth with almost no side effects? The answer lies in its mechanism of action as a selective androgen receptor modulator.

SARMs like Andarine S4 mimic the effects of anabolic steroids, but are far more selective in the androgen receptors they bind to. While steroids bind to any androgen receptor they find, SARMs like Andarine only bind to the “good ones” and not the ones that cause side effects.

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That isn't to say that Andarine S4 is totally side effect free, but there's a reason why SARMs are so popular. In general, they're a great way to get rapid muscle growth you'd get from a cycle of steroids, with less than around 5-10% of the side effects.

History of Andarine

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Andarine was initially developed to be a better and stronger version of Ostarine, with a high oral bioavailability and strong ability to fight muscle wasting, it seemed like a good alternative.

Here's a brief history of Andarine S4's development:

  • 2003 – Andarine is first synthesized & discovered [R]
  • 2004 – GTx and Ortho Biotech enter joint collaboration to research Andarine [R]
  • 2005 – Phase I clinical trials completed, according to GTx Annual Report

Despite my most intense research efforts, there's very few other compounds that have this little information on their development compared to Andarine S4. Allegedly, the company is going through Phase II clinical trials, but there is little trace of this online.

Regardless, bodybuilders have been using Andarine for years, and there's an enormous amount of anecdotal evidence and research studies to pull from, so we know all we need to know about how to use this drug safely.

Is Andarine legal? The short answer is yes, Andarine is legal to buy and sell online, and is 100% legal to possess. So, if you want to do a cycle of Andarine, no need to worry.

Andarine is classified as a research compound, which means it's legal to buy and sell for research purposes. Technically it is not FDA approved for human consumption yet, and is still undergoing human trials to determine its long term safety.

As long as you don't literally take Andarine in front of a cop, you should be fine. There has yet been a case to date where someone is being arrested for consuming or using SARMs.

Andarine Benefits

Andarine S4 is an amazing compound for a bulking cycle or a cutting cycle, due to its ability to shred off body fat like no other SARM. Yes, it will help you build lean muscle mass, but it is primarily focused on fat loss and getting shredded.

Here's some scientifically proven benefits of Andarine:

  • Pack on Lean Muscle Mass
  • Improved Bone Density
  • Accelerated Fat Burning
  • Less Water Retention

In a nutshell, Andarine creates the perfect anabolic environment in your body to encourage a healthy body composition, muscle growth, and muscles that “pop” and look shredded.

Dosage & Cycle Facts

What's the best Andarine dosage? There is no “best dosage” because what's best will vary depending on your own individual body, your goals, your workout routine, and more.

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That being said, here are the Andarine dosage guidelines:
  • Beginner Dosage: 25mg/day
  • Intermediate Dosage: 50mg/day
  • Advanced Dosage: 75mg/day

Most users do very well on a low dosage of 25-50mg/day. This is more than enough to pack on some serious muscle mass and shred off any of your body's stored fat over the past few years.

In general, with Andarine S4, you'll want to take time off your cycle. Usually the rule is whatever your time on is, that should be your time off, so your body adjusts.

This means, if you take Andarine for 8 weeks, it's best to take at least 8 weeks off, followed by a post cycle therapy (PCT). We will explain more on this down below.

Andarine PCT

testomax SARMs pct benefits

Does Andarine require a PCT? While the research is not clear on this, what is clear is that Andarine does lead to mild testosterone suppression, and while your body can probably recover naturally, it's best to just use a PCT and speed up the process.

Using a PCT after an Andarine cycle will ensure that you keep the muscle mass you put on during your cycle, and don't lose too much strength as your body transitions off.

For PCT, we recommend Testomax. Just one bottle is more than enough to run your entire PCT – no need to go with a strong PCT like Nolvadex and Clomid, that's overkill for SARMs.


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In summary, Andarine is an amazing way to get some great muscle gains and shred off a ton of fat in just 8-12 weeks. It's a very potent SARM that exerts a strong anabolic effect on the body.

Be sure to use this compound safely, and always get it from a good source. We recommend you get it through any of the vendors on our official list of the best companies with SARMs for sale.

LEGAL DISCLAIMER: The information on this page is intended for entertainment and information purposes only. It is not a substitute for professional medical advice. Always check your local jurisdiction’s laws before buying anything or doing anything. SARMs are strictly for research purposes only, and are not FDA approved to treat any condition.